
Biotech Expert Manny Otero, PhD, on Trends Shaping Startups
José Manuel (Manny) Otero, PhD, Chief Technical Officer at Lexeo Therapeutics shares a roadmap for early-stage biotechs.
Lexeo Therapeutics is a New York City-based, clinical stage genetic medicine company dedicated to transforming healthcare by applying pioneering science to fundamentally change how genetically defined cardiovascular diseases and APOE4-associated Alzheimer’s disease are treated. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of cardiovascular and APOE4-associated Alzheimer’s disease programs.
Our mission is to transform healthcare by pushing boundaries in developing meaningful genetic medicines for diseases, regardless of prevalence. By taking aim at the underlying genetic cause of the devastating diseases we target, Lexeo seeks to create substantial positive impact and reduce the overwhelming burdens placed on people receiving treatment, their caregivers, and healthcare systems.
Lexeo currently has three programs in clinical trials with multiple data readouts expected in 2024.
Lead programs include Phase 1/2 trials of LX2006 for the treatment of Friedreich's ataxia (FA) cardiomyopathy, LX1001 for the treatment of APOE4-associated Alzheimer’s disease and LX2021 for the treatment of arrhythmogenic cardiomyopathy caused by mutations in the PKP2 gene (PKP2-ACM).
Building on groundbreaking research from Weill Cornell Medicine and the University of California San Diego, Lexeo partners with preeminent institutions on the cutting edge of gene therapy research.
José Manuel (Manny) Otero, PhD, Chief Technical Officer at Lexeo Therapeutics shares a roadmap for early-stage biotechs.
What's ahead for gene therapy? R. Nolan Townsend, MBA, co-founded LEXEO Therapeutics to focus on bringing precision genetic medicines to patients with genetic cardiovascular diseases and Alzheimer’s.
Lexeo Therapeutics is innovating not just genetic modifications as therapies for target diseases, but also manufacturing and clinical studies.
Lexeo Therapeutics is developing pioneering treatments for genetically defined cardiovascular diseases and APOE4-associated Alzheimer’s disease.
Before he became CEO of Lexeo Therapeutics, R. Nolan Townsend, MBA, worked across Pfizer, in Finance, Corporate Strategy, Operations and Marketing, and Rare Disease in North America, Asia, Africa/Middle East and Europe.
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