Top Institutes and Centers

Every institute and center on this list represents the best in U.S. biomedical research. We ranked 60 institutions on their translational performance, using criteria built to reflect how these organizations operate and fund their research.

Mass General Brigham ranks first among biomedical institutes in the Cure Innovation Index. Based in Boston, Massachusetts, the institute leads in both Research Capabilities and Market Translation, and places in the top tier for Entrepreneurial Readiness.

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Mass General Brigham
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Mayo Clinic

Rochester, MN

Mayo Clinic ranks second among the 60 biomedical institutes in the Cure Innovation Index, based in Rochester, Minnesota. The institute places fifth in both Research Capabilities and Market Translation, and second in Entrepreneurial Readiness, a profile that leans toward the translation and commercialization end of the innovation spectrum.

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Mayo Clinic

Scripps Research Institute ranks third among the 60 biomedical institutes in the Cure Innovation Index and is based in San Diego, California. The institute places fourth in Research Capabilities and second in Market Translation, a pairing that reflects a balance between scientific discovery and translational work.

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Scripps Research Institute

Memorial Sloan Kettering Cancer Center ranks fourth among the 60 biomedical institutes in the Cure Innovation Index, based in New York, New York. The center places second in Research Capabilities and sixth in Market Translation, a pairing that points to strength across both discovery science and the processes that move findings toward clinical application.

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Memorial Sloan Kettering Cancer Center

Dana-Farber Cancer Institute, located in Boston, Massachusetts, ranks fifth among biomedical institutes in the Cure Innovation Index. The institute performs in the upper tier across both research capabilities, ranking sixth, and market translation, ranking third.

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Dana–Farber Cancer Institute

Cleveland Clinic Lerner College of Medicine ranks sixth among biomedical institutes in the Cure Innovation Index, based in Cleveland, Ohio. Its defining strength is entrepreneurial readiness, where it places second among its peers, supported by an incubator, an entrepreneur-in-residence program, and dedicated entrepreneurship training.

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Cleveland Clinic Lerner College of Medicine

Fred Hutchinson Cancer Center, located in Seattle, Washington, ranks seventh among the 60 biomedical institutes evaluated in the Cure Innovation Index. Its research capabilities rank third in the category, reflecting sustained depth in discovery science.

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Fred Hutchinson Cancer Center

Children's Hospital of Philadelphia ranks eighth among biomedical institutes in the Cure Innovation Index and is located in Philadelphia, Pennsylvania. The hospital shows strength across all three domains, with its highest standing in Entrepreneurial Readiness, where it ranks fifth.

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Children's Hospital of Philadelphia

The Broad Institute of MIT and Harvard ranks ninth among 60 biomedical research institutions in the Cure Innovation Index, based in Cambridge, Massachusetts. Its profile leans toward market translation, where it places fourth, and research capabilities are strong.

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Broad Institute of MIT and Harvard

Cincinnati Children's Hospital Medical Center ranks 10th among biomedical institutes in the Cure Innovation Index and is located in Cincinnati, Ohio. Its strongest domain is Entrepreneurial Readiness, where it ranks fifth, supported by an incubator, an entrepreneur-in-residence program, and faculty-led clinical trials.

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Cincinnati Children's Hospital Medical Center
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Cure Innovation Index Methodology

From a pool of more than 6,000 institutions, the top 303 were ranked using two dozen indicators — from scientific foundation and lab infrastructure to patents, products, and partnerships — drawn from more than a dozen federal and commercial databases, an original audit of all institutions, and surveys of more than 3,300+ scientists, industry leaders, and biomedical experts.

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Innovation isn't a single moment — it's an entire ecosystem. The Index evaluates institutions across two dozen indicators, grouped in three core domains that reveal the full picture of what it takes to turn groundbreaking science into real-world impact.

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