Top Institutes and Centers
Every institute and center on this list represents the best in U.S. biomedical research. We ranked 60 institutions on their translational performance, using criteria built to reflect how these organizations operate and fund their research.
Mass General Brigham
Mass General Brigham ranks first among biomedical institutes in the Cure Innovation Index. Based in Boston, Massachusetts, the institute leads in both Research Capabilities and Market Translation, and places in the top tier for Entrepreneurial Readiness.
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Mayo Clinic
Mayo Clinic ranks second among the 60 biomedical institutes in the Cure Innovation Index, based in Rochester, Minnesota. The institute places fifth in both Research Capabilities and Market Translation, and second in Entrepreneurial Readiness, a profile that leans toward the translation and commercialization end of the innovation spectrum.
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Scripps Research Institute
Scripps Research Institute ranks third among the 60 biomedical institutes in the Cure Innovation Index and is based in San Diego, California. The institute places fourth in Research Capabilities and second in Market Translation, a pairing that reflects a balance between scientific discovery and translational work.
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Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Cancer Center ranks fourth among the 60 biomedical institutes in the Cure Innovation Index, based in New York, New York. The center places second in Research Capabilities and sixth in Market Translation, a pairing that points to strength across both discovery science and the processes that move findings toward clinical application.
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Dana–Farber Cancer Institute
Dana-Farber Cancer Institute, located in Boston, Massachusetts, ranks fifth among biomedical institutes in the Cure Innovation Index. The institute performs in the upper tier across both research capabilities, ranking sixth, and market translation, ranking third.
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Cleveland Clinic Lerner College of Medicine
Cleveland Clinic Lerner College of Medicine ranks sixth among biomedical institutes in the Cure Innovation Index, based in Cleveland, Ohio. Its defining strength is entrepreneurial readiness, where it places second among its peers, supported by an incubator, an entrepreneur-in-residence program, and dedicated entrepreneurship training.
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Fred Hutchinson Cancer Center
Fred Hutchinson Cancer Center, located in Seattle, Washington, ranks seventh among the 60 biomedical institutes evaluated in the Cure Innovation Index. Its research capabilities rank third in the category, reflecting sustained depth in discovery science.
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Children's Hospital of Philadelphia
Children's Hospital of Philadelphia ranks eighth among biomedical institutes in the Cure Innovation Index and is located in Philadelphia, Pennsylvania. The hospital shows strength across all three domains, with its highest standing in Entrepreneurial Readiness, where it ranks fifth.
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Broad Institute of MIT and Harvard
The Broad Institute of MIT and Harvard ranks ninth among 60 biomedical research institutions in the Cure Innovation Index, based in Cambridge, Massachusetts. Its profile leans toward market translation, where it places fourth, and research capabilities are strong.
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Cincinnati Children's Hospital Medical Center
Cincinnati Children's Hospital Medical Center ranks 10th among biomedical institutes in the Cure Innovation Index and is located in Cincinnati, Ohio. Its strongest domain is Entrepreneurial Readiness, where it ranks fifth, supported by an incubator, an entrepreneur-in-residence program, and faculty-led clinical trials.
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Cure Innovation Index Methodology
From a pool of more than 6,000 institutions, the top 303 were ranked using two dozen indicators — from scientific foundation and lab infrastructure to patents, products, and partnerships — drawn from more than a dozen federal and commercial databases, an original audit of all institutions, and surveys of more than 3,300+ scientists, industry leaders, and biomedical experts.
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Innovation isn't a single moment — it's an entire ecosystem. The Index evaluates institutions across two dozen indicators, grouped in three core domains that reveal the full picture of what it takes to turn groundbreaking science into real-world impact.
Insights From the Cure Innovation Index




